For opioid-naive patients, what is the recommended approach to initiating opioid therapy for pain?

• A. Immediately administer high-dose opioids to ensure relief.
• B. Start low, go slow; titrate cautiously while monitoring analgesia and side effects.
• C. Rely solely on nonpharmacologic methods.
• D. Delay opioids until pain is unmanageable.

Answer: (B)